Table 3a.
Multivariate analysis of risk factors for post-operative hepatic insufficiency (PHI) and major complications after major hepatectomy
| Variable | PHI | Major complications | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Male gender | 1.15 | 0.63–2.11 | 0.637 | 1.21 | 0.79–1.86 | 0.366 |
| ASA class | 1.93 | 1.05–3.54 | 0.040 | 1.66 | 1.07–2.55 | 0.024 |
| Pre-op albumin | 0.65 | 0.38–1.08 | 0.103 | 0.61 | 0.40–0.93 | 0.019 |
| Pre-op INR | 3.88 | 0.90–16.68 | 0.068 | 2.50 | 0.47–12.50 | 0.290 |
| Pre-op total bilirubin | 1.24 | 1.06–1.45 | 0.006 | 1.02 | 0.87–1.11 | 0.755 |
| Portal vein embolization | 2.12 | 0.75–5.93 | 0.159 | 1.19 | 0.49–2.87 | 0.712 |
| Bile duct resection | 1.26 | 0.63–2.54 | 0.524 | 1.22 | 0.73–2.03 | 0.461 |
| EBL | 1.00 | 1.00–1.001 | 0.141 | 1.01 | 1.00–1.02 | 0.198 |
| Intra-op transfusion | 1.09 | 0.52–2.31 | 0.818 | 1.20 | 0.68–2.13 | 0.533 |
| Cancer diagnosis | 1.43 | 0.67–3.07 | 0.356 | 1.96 | 1.13–3.39 | 0.022 |
| Cirrhosis | 1.76 | 0.56–5.55 | 0.363 | 2.63 | 1.01–6.82 | 0.047 |
| POD2 phosphorus > 2.4 | 1.78 | 1.02–3.17 | 0.048 | 1.57 | 1.02–2.47 | 0.049 |
Statistically significant variables (P < 0.05) indicated in bold. HR, hazard ratio; CI, confidence interval; ASA, American Society of Anesthesiology; EBL, estimated blood loss; POD, post-operative-day 2.