Table 4.

Nucleic acid discordance between plasma and non-plasma sequence pairs by treatment status and subtype

		DBS	DPS	STP	STB
Total
	N	33	15	34	5
	% Discordance; Range	1.1; 0.4–2.3	1.2; 0.3–2.2	2.0; 0.5–7.1	2.3; 0.8–5.3
Patient stratum
Treated
	N	17	5	7a	0
	% Discordance; Range	1.1; 0.4–2.2	0.9; 0.3–1.3	1.2; 0.7–2.0	–
Naïve
	N	16b	10b	27	5
	% Discordance; Range	1.2; 0.5–2.3	1.4; 0.4–2.2	2.2; 0.5–7.1	2.3; 0.8–5.3
Treated vs. Naïve	RR (95% CI), p	0.9 (0.7, 1.3) p=0.70	0.7 (0.5, 1.1) p=0.09	0.6 (0.4, 0.8) p=0.002	–
Subtype
A
	N	17	10	18b	2
	% Discordance; Range	1.1; 0.4–2.3	1.3; 0.7–2.0	2.0; 0.5–4.7	2.0; 1.4–2.6
D
	N	6	2	5	0
	% Discordance; Range	1.0; 0.4–2.2	1.5; 0.9–2.2	1.0; 0.7–1.6	–
D vs. A	RR (95% CI), p	0.9 (0.5, 1.6) p=0.64	1.1 (0.8, 1.6) p=0.50	0.5 (0.4, 0.7) p<0.001	–
Viral load
Per 1-log unit higher	RR (95% CI) p	0.7 (0.6, 0.9) p=0.001	0.9 (0.7, 1.4) p=0.31	0.9 (0.6, 1.3) p=0.59	0.8 (0.5, 1.3) p=0.32

Numbers represent mean (range) percent discordance. RR, rate ratios (95% confidence interval) of discordant nucleic acids comparing patient treatment status and subtype by analyte type. “–” means that there were no STB/plasma sequence pairs;

^atwo missing protease sequences;

^bone missing protease sequence. DBS, dried blood spots. DPS, dried plasma spots. STP, ViveST plasma. STB, ViveST blood.