Table 5. QTL candidate gene SNPs associated with aggressive prostate cancer in CGEMS GWAS.

Chr.	Candidate Gene	SNP Distance From Gene (bp)	SNP	PLCO Variable	Odds Ratio (95% C.I.)	Minor Allele Frequency		t stat	P value	Permutation P value
						Aggressive Disease	Non-Aggressive Disease
5q31.1	CXCL14	97285	rs801564	pros_stage_n	1.05 (1.01–1.09)	0.001	0.282	2.587	0.010	0.011
		47017	rs10515473	pros_gleason_prost	0.72 (0.59–0.88)	0.163	0.122	−3.148	0.002	0.001
6p22.1	HIST1H3E	6834	rs933199	pros_gleason	0.75 (0.62–0.92)	0.032	0.025	−2.759	0.006	0.006
		17168	rs198806	pros_gleason_prost	0.77 (0.63–0.93)	0.218	0.172	−2.643	0.008	0.009
	PGBD1	31884	rs1233708	pros_stage	1.08 (1.02–1.13)	0.042	0.213	2.921	0.004	0.004
6p22.2	HIST1H1A	13705	rs6910741	pros_stage_n	0.94 (0.90–0.98)	0.002	0.144	−2.620	0.009	0.009
6p22.3	GPLD1	0	rs793663	pros_gleason_prost	1.32 (1.09–1.60)	0.186	0.195	2.854	0.004	0.004
		37981	rs3789224	pros_stage_m	1.08 (1.02–1.13)	4.06E-04	0.127	2.627	0.009	0.010
6q15	AKIRIN2	0	rs7755167	pros_gleason	0.86 (0.78–0.95)	0.246	0.221	−3.107	0.002	0.002
	ORC3	40224	rs9450716	pros_gleason	1.16 (1.05–1.28)	0.161	0.189	3.042	0.002	0.002
9p13.3	CCL19	80925	rs3802427	pros_stage_m	1.09 (1.04–1.15)	4.06E-04	0.162	3.557	3.89E-04	3.00E-04
	KIAA1045	78052	rs10123308	pros_gleason_prost	1.30 (1.08–1.57)	0.212	0.216	2.773	0.006	0.005
9p21.2	MOB3B	3431	rs3849942	pros_stage_t	2.15 (1.41–3.28)	0.161	0.075	3.564	3.80E-04	5.00E-04
		0	rs3739530	pros_gleason	0.80 (0.70–0.93)	0.075	0.056	−2.996	0.003	0.002
		74176	rs1853186	pros_stage	0.94 (0.90–0.98)	0.079	0.272	−2.730	0.006	0.006
		0	rs10121765	pros_gleason_prost	0.77 (0.64–0.93)	0.260	0.209	−2.776	0.006	0.005
16p11.2	ITGAX	9009	rs8045738	pros_gleason_prost	1.33 (1.08–1.62)	0.141	0.148	2.753	0.006	0.007
16q12.2	LPCAT2	19704	rs3764263	pros_stage_t	1.61 (1.12–2.31)	0.324	0.134	2.591	0.010	0.009
		0	rs289707	pros_gleason_biop	1.22 (1.07–1.38)	0.075	0.126	3.059	0.002	0.002
		72508	rs2289119	pros_stage_n	1.06 (1.01–1.10)	0.001	0.187	2.591	0.010	0.009
		0	rs17369578	pros_gleason	1.41 (1.13–1.77)	0.020	0.026	2.976	0.003	0.003
20p11.21	GZF1	836	rs6076072	pros_stage_t	2.17 (1.21–3.92)	0.068	0.035	2.589	0.010	0.008
20p13	NSFL1C	4463	rs6042568	pros_gleason	0.75 (0.62–0.90)	0.037	0.029	−3.007	0.003	0.003

QTL candidate genes also identified as having a dysregulated expression in prostate cancer gene expression datasets are denoted in bold typeface.