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. 2014 Nov 20;8(11):e3276. doi: 10.1371/journal.pntd.0003276

Figure 1. Effect of emodepside and diethylcarbamazine on SLO-1 K+ currents.

Figure 1

A: Representative leak-subtracted K+ current traces of the control current, 100 µM diethylcarbamazine effect, 1 µM emodepside plus 100 µM diethylcarbamazine effect and the post-emodepside current at the 0 mV step potential. The post drug currents were measured after 20 min wash in drug-free solution. B: Bar chart (mean ± SEM) of % increase in the K+ currents at the step potential of 0 mV produced by 100 µM diethylcarbamazine (p<0.01, n = 4, paired t-test), 1 µM emodepside plus 100 µM diethylcarbamazine (p<0.01, n = 4, paired t-test) and at the post-drug (emodepside) 20-min period (p<0.01, n = 4, paired t-test).