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. 2014 Nov 20;9(11):e112909. doi: 10.1371/journal.pone.0112909

Figure 3. Developmental alignment of Group 3 and Group 4 medulloblastoma.

Figure 3

a. The expression levels of selected exclusively Group 3 over-expressed photoreceptor and glutamate signaling genes were graphed for all sample groups using Box-Whisker plots. b. Expression of rod photoreceptor genes transiently and terminally expressed during retinal differentiation was graphed for all medulloblastoma and control samples. The mean expression and the time window of active rod gene expression for Group 3 medulloblastoma is indicated and emphasized by yellow shaded overlay. c. Developmental alignment of key transcription factors expressed during glutamatergic granule neuron development. Expression time frame during normal cerebellar maturation is indicated schematically in the top panel. Gene expression for medulloblastoma and control groups is shown in box-whisker plots. Developmental expression windows of time stamp genes in medulloblastoma subgroups are schematically displayed in the bottom panel. *** −p<0.001, $ –p<0.05 compared to all control groups with n>1 and exclusive for molecular subgroup, ∧ −p<0.05 compared to all control groups but not exclusive for medulloblastoma subgroup, NFB - normal fetal brain, NFGM - normal fetal germinal matrix, NPC - neural progenitor cells, NSC - neural stem cells.