Table 1. Pathway enrichment of medulloblastoma-associated co-expression cluster families.

		Enriched pathways	p<	Contributing genes
WNT brown cluster	(342 probes)	Wnt/β-catenin Signaling	0.002	FZD10, CDH2, WIF1, DKK4, WNT16, DKK2, LEF1, DKK1, FZD7
		Glioblastoma Multiforme Signaling	0.003	FZD10, PDGFRA, CDK6, WNT16, PLCB1, LEF1, PDGFC, FZD7
		Basal Cell Carcinoma Signaling	0.006	FZD10, BMP4, WNT16, LEF1, FZD7
		Ovarian Cancer Signaling	0.006	FZD10, LHCGR, WNT16, LEF1, MMP2, PDGFC, FZD7
SHH cluster family B)	(358 probes)	Hepatic Fibrosis	0.002	COL1A2, COL1A1, IGFBP4, FGFR1, IGFBP5, PGF, COL3A1, EGFR
		Molecular Mechanisms of Cancer	0.003	RAP2B, A XIN1, ARHGEF7, PTCH1, PTCH2, FOXO1, GAB1, RHOB, MAPK10, BID, MAP2K3, CDK2, CTNND1
		Basal Cell Carcinoma Signaling	0.005	GLI2, AXIN1, PTCH1, DVL3, PTCH2
		Sonic Hedgehog Signaling	0.010	GLI2, PTCH1, PTCH2
Group 3 cluster family D	(508 probes)	Phototransduction Pathway	3.89E−10	PDE6G, GUCA1A, GNGT1, GNB5, PRKAR2A, PDE6H, GNB3, GNAT1, RHO, PDC, SAG, CNGB1, RCVRN
		Protein Kinase A Signaling	0.0087	RAF1, PDE6G, MYL6, PTP4A3, GNB5, PRKAR2A, MYL6B, PTPRF, PDE6H, GNB3, RHO, PPP1R10, TGFB1, TGFB3, CNGB1, TNNI1, CDC25A, MTMR3
		Cyclins and Cell Cycle Regulation	0.0138	RAF1, TGFB1, ABL1, TGFB3, HDAC5, CDC25A
		Estrogen Receptor Signaling	0.0141	CTBP1, RAF1, POLR2A, NCOR2, MED24, TRRAP, MED27, SMARCA4
Group 4 cluster family E	(343 probes)	Semaphorin Signaling in Neurons	1.23E−05	RND2, CRMP1, DPYSL3, DPYSL4, DIRAS3, RAC1, FNBP1
		Glioblastoma Multiforme Signaling	7.41E−05	RND2, SRC, TSC1, DIRAS3, IGF1R, RAC1, PLCL2, CDKN1B, PLCH2, FNBP1
		Axonal Guidance Signaling	1.20E−04	NTF3, ITSN1, EPHB2, TUBB2A, RAC1, PLXNA2, PLCL2, GNAZ, PLCH2, NCK2, SRGAP3, PRKAR2B, TUBA1A, PTPN11, PPP3CB, GNAO1, BAIAP2
		Gap Junction Signaling	1.23E−04	DBN1, HTR2C, SRC, PRKAR2B, TUBA1A, PPP3CB, ADCY1, TUBB2A, PLCL2, PLCH2
		Actin Nucleation by ARP-WASP Complex	1.91E−04	RND2, NCK2, DIRAS3, BAIAP2, RAC1, FNBP1
		Cardiac Hypertrophy Signaling	0.001	RND2, PRKAR2B, PPP3CB, DIRAS3, GNAO1, ADCY1, IGF1R, PLCL2, GNAZ, PLCH2, FNBP1
		Ephrin B Signaling	0.001	NCK2, ITSN1, EPHB2, GNAO1, RAC1, GNAZ
		RhoGDI Signaling	0.001	RND2, SRC, DIRAS3, GNAO1, RAC1, PIP4K2B, CDH18, GNAZ, FNBP1
		Sphingosine-1-phosphate Signaling	0.001	RND2, DIRAS3, ADCY1, RAC1, PLCL2, PLCH2, FNBP1
		Regulation of Actin-based Motility by Rho	0.001	RND2, DIRAS3, BAIAP2, RAC1, PIP4K2B, FNBP1
		Clathrin-mediated Endocytosis Signaling	0.002	SRC, ARRB1, PPP3CB, EPHB2, SH3GL3, RAC1, HIP1, FGF13, HIP1R
		Neuregulin Signaling	0.002	SRC, PTPN11, ERBB4, CDKN1B, STAT5B, CDK5R1