Table 4. Comparison of biochemical and treatment factors associated with outcome.
Factors | End-point | p | |
NO (n = 56) | YES (n = 23) | ||
Complement C3 at biopsy | 1.05±0.41 | 1.23±0.62 | 0.311 |
Low complement C3 at biopsy (%) | 14.3 | 17.4 | 0.706 |
Complement C4 at biopsy | 0.36±0.33 | 0.37±0.19 | 0.891 |
Low complement C4 at biopsy (%) | - | - | - |
Serum cholesterol (mmol/L) | 6.1±1.4 | 7.9±3.2 | 0.079 |
Serum albumin at biopsy (g/L) | 26.1±6.9 | 25.2±8.2 | 0.667 |
Serum creatinine at biopsy (µmol/L) | 124.7±86.9 | 315.2±229.0 | 0.001 |
Estimated MDRD GFR at biopsy (ml/min) | 75.3±30.6 | 40.5±34.0 | <0.0001 |
Proteinuria at biopsy (g/day) | 8.1±6.9 | 8.3±5.2 | 0.872 |
Treatment with ACE-i/ARB (%) | 92.9 | 87.0 | 0.409 |
Treatment with prednisone (%) | 25.0 | 52.2 | 0.034 |
Treatment with cyclophosphamide (%) | 8.9 | 26.1 | 0.071 |
Treatment with Azathioprine (%) | 3.6 | 8.7 | 0.635 |
MDRD – Modification of Diet in Renal Disease; GFR – Glomerular filtration rate; ACE-I – Angiotensin converting enzyme inhibitors; ARB – Angiotensin receptor blockers.