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. 2014 Nov 20;9(11):e113259. doi: 10.1371/journal.pone.0113259

Figure 4. Intra-day variation in paraxanthine.

Figure 4

A. In all patients. At 6:30 AM: 0.75×10−3 (95% CI, 0.28–2.7×10−3) in patients with cachexia vs. 3.61×10−3 (1.91–5.48×10−3) pg/ml in those without cachexia, p = 0.35; TNF-α: 7.1 (1.2 to 30.2) vs. 3.3 (1.2 to 30.0) pg/ml, p = 0.27; leptin: 2.4 (1.0 to 9.8) vs. 4.0 (2.0 to 9.9) ng/ml, p = 0.27, respectively. B. In male patients. IL-6: 15.2 (range, 2.6 to 23.4) in patients with cachexia vs. 9.4 (1.4 to 28.7) pg/ml in those without cachexia, p = 0.57; TNF-α: 12.4 (1.2 to 29.0) vs. 3.2 (1.4 to 28.6) pg/ml, p = 0.29; leptin: 2.3 (1.0 to 8.8) vs. 3.45 (2.0 to 2.8) ng/ml, p = 0.34, respectively.