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. 2014 Nov 20;10(11):e1004524. doi: 10.1371/journal.ppat.1004524

Figure 6. HCMV-specific serum NAb titers in vaccinated RM.

Figure 6

Groups of four RM were vaccinated three times with MVA recombinants by intramuscular (i.m.) injection. HCMV-specific serum NT50 titers were determined at multiple time points on ARPE-19 cells, MRC-5 fibroblasts and HUVEC using HCMV TB40/E for infection. A) Schedule for vaccination and sample preparation. B-E) Serum NT50 titer of individual RM vaccinated with MVA-gH/gL-PC (B, C) or MVA-gH/gL (D, E) measured on ARPE-19 and MRC-5 cells. F) Comparison of serum NT50 titers determined in MVA-gH/gL-PC or MVA-gH/gL vaccine groups (GMT; n = 4) on ARPE-19 and MRC-5. Serum from RM vaccinated with MVA-Venus was analyzed as a control. G) Serum NT50 titer in vaccine groups (GMT, n = 4) measured on ARPE-19 cells and HUVECs at weeks 8 and 26 post-initial vaccination. Filled arrowheads indicate vaccinations. Dotted lines represent detection limits. Upper bars represent 95% confidence intervals.