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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Oct 2;34(12):2594–2600. doi: 10.1161/ATVBAHA.114.303974

Figure 3. Hb α X peptide increases nitric oxide signaling in the vessel wall of wild type but not eNOS−/− mice.

Figure 3

a, Measurement of cGMP accumulation following phenylephrine stimulation in thoracodorsal arteries pretreated with Scr X or Hb α X peptide in the presence or absence of L-NAME (n=3). b, Dose response to phenylephrine on arteries treated with Scr X or Hb α X in the presence or absence of L-NAME. c, Cumulative dose response curve on thoracodorsal arteries from eNOS−/− mice with Scr X or Hb α X. In b and c, n indicates the number of arteries; value in parentheses shows the number of mice. In b and c, * indicates significance between Scr X vs. Hb α X, ^ indicates significance between Hb α X vs. Hb α X + L-NAME analyzed using 1-way ANOVA. All error bars represent s.e.m.