Skip to main content
. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Oct 2;34(12):2594–2600. doi: 10.1161/ATVBAHA.114.303974

Figure 5. Hb α X reverses angiotensin II-induced hypertension.

Figure 5

a, Mean arterial pressure measurements using radiotelemetry from C57BL/6 mice or mice continuously infusion of angiotensin II for five days via osmotic minipump. b, Proximity ligation assay for eNOS and Hb α (red punctuates) on transverse sections of a mouse thoracodorsal artery isolated from Ang-II hypertensive animals with and without Hb α X (5mg/kg). c, systolic, diastolic and mean arterial pressure measurements following injection of Scr X or Hb α X peptide (all 5 mg/kg) in angiotensin II-induced hypertensive mice. Significant differences between saline or Scr X and Hb α X analyzed by a t-test (a) and 1-way ANOVA followed by a Bonferroni’s post-hoc test (b,c). * and # indicates significance between saline and Hb α X or Scr X and Hb α X (p<0.05). n≥5 mice for all conditions; error bars indicate s.e.m.