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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Oct 2;34(12):2563–2569. doi: 10.1161/ATVBAHA.114.304244

Figure 4. Effect of combined partial or complete Par4 and GPVI deficiency on tail bleeding.

Figure 4

Blood loss after tail transection was measured in anesthetized 28 ± 3 day-old mice with the indicated Gp6 and Par4 genotypes. Mean ± SEM (n=13–22) hemoglobin loss is shown. Par4 and Gp6 genotypes each had statistically significant effects and interactions by 2-way ANOVA (all P<0.0001). By Tukey's test, blood loss in all Par4−/− genotypes was different from that in all Par4+/+ and Par+/− genotypes regardless of Gp6 genotype (P<0.001). By contrast, blood loss in Gp6+/− and Gp6−/− mice was not different from that in Gp6+/+ mice in Par4+/+ or Par4+/− backgrounds, but blood loss in Gp6+/−:Par4−/− mice and Gp6−/−:Par4−/− mice was significantly different from that in Gp6+/+:Par4−/− mice (P<0.001).