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. Author manuscript; available in PMC: 2014 Nov 21.
Published in final edited form as: Drug Deliv Transl Res. 2011 Sep 10;1(5):383–394. doi: 10.1007/s13346-011-0038-y

Fig. 5.

Fig. 5

Representative images from histopathologic analysis of the uterus and vagina. Treatment of AdCre-infected wild-type or LSL-K-RasG12D/+ PtenloxP/loxP mice with nanoparticles did not result in pathologic changes beyond those seen in untreated AdCre-infected mice. Pathologic conditions observed after infection with AdCre included: increased vaginal inflammation, uterine dilation (***), and uterine fibrosis. Uterine fibrosis was confirmed by the presence of collagen (blue) by Masson’s trichrome (MT) staining. A single LSL-K-RasG12D/+ PtenloxP/loxP mouse infected with AdCre and treated with NP (CPT) had a focus of squamous hyperplasia with orderly progression of squamous epithelial cells from the basement membrane (*) to the surface (**) in the vagina. Additionally, a single LSL-K-RasG12D/+ mouse infected with AdCre had a uterine polyp (arrow). Scale bars 200 µm