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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Immunol. 2014 Oct 31;193(11):5613–5625. doi: 10.4049/jimmunol.1401161

Figure 6. In vivo relationships between SIV-specific CTL and SIV RNA+ cells within compartments of lymph node (LN) and spleen from chronically infected rhesus macaques.

Figure 6

(A) Effector to target cell ratios of SIV-specific CTL to SIV RNA+ cells were significantly higher in extrafollicular (EF) compared to follicular compartments (F) for both lymph node (n=8) and spleen (n=6). (B) Frequencies of SIV-specific CTL within F and EF predicted frequencies of SIV RNA+ cells within those compartments in a mixed model analysis that controlled for tissue type. For every 1 log10 increase in SIV-specific CTL, there was on average a −0.96 change in log10 SIV RNA+ cells (95% CI, −1.31,−0.61). Results for spleen are summarized by the dotted line and for lymph node by the solid line. If data were available for more than one CTL epitope in an animal, only the most abundant SIV-specific CTL response was evaluated. If data were available for multiple lymph nodes in an animal, results were averaged.