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. 2015 Jan;88:63–73. doi: 10.1016/j.neuropharm.2014.09.021

Fig. 10.

Fig. 10

Staurosporine reduces THDOC potentiation at α4S443Aβ3δ, but not at α4S443Aβ3S408A,S409Aδ GABAA receptors. (A) Mean peak currents recorded from HEK293 cells expressing α4S443Aβ3δ (top panel: n = 7) or α4S443Aβ3S408A,S409Aδ (bottom panel: n = 7) GABAA receptors in response to EC20 GABA or EC20 GABA + 50 nM THDOC. Cells were treated with 200 nM staurosporine. (B) Bar chart showing the mean potentiation of EC20 GABA-activated currents by 50 nM THDOC before (black bars) and after (grey bars) staurosporine treatment in cells expressing α4β3δ (n = 9), α4S443Aβ3δ (n = 7) or α4S443Aβ3S408A,S409Aδ (n = 7) GABAA receptors. Data for α4β3δ receptors is taken from Fig. 8. *P < 0.05, paired t-test.