Table 1.

MicroRNAs altered in MSCs by myeloma

miR name	Fc, 3D model (MSCs in coculture with MM1S vs alone)	P value, 3D model (MSCs in coculture with MM1S vs alone)	Fc, MM vs ND MSCs	P value, MM vs ND MSCs
hsa-miR-199a-5p	–2.019	.00086974	–1.917	.00115665
hsa-miR-181a-5p	1.771	.00362835	3.190	.02106839
hsa-miR-181c-5p	2.135	.00276756	3.078	.00192591
hsa-miR-222-3p	2.152	.00332040	1.821	.01680615
hsa-miR-601	2.546	.00738047	3.637	.02449335
hsa-miR-146a-5p	17.175	.00405939	15.353	.02622689

Six miRs were found to be similarly upregulated (5 miRs) or downregulated (1 miRs) in the 3D system (MSCs cocultured with GFP⁺MM1S vs MSCs alone, after 2 weeks in coculture in osteogenic, no-dexamethasone media) and in patient vs normal samples (MM patient MSCs vs normal donor MSCs). Fc ≥1.5, P < .05, n ≥3, 2-tailed Student's t test, average expression >25 nanoString counts.