Table 2.
Adjusted HRs of ischemic stroke for patients followed from baseline to study end
| Mild TBI group (n = 24,905) | Control group (n = 719,811) | ||
|---|---|---|---|
| Variables | Hazard ratio | 95% confidence interval | P-value |
| Mild TBI | 1.46 | 1.33—1.62 | <0.001 |
| Male | 1.47 | 1.41—1.53 | <0.001 |
| Patient age | 1.07 | 1.06—1.07 | <0.001 |
| Socioeconomic status | |||
| Low | 1 | -- | -- |
| Moderate | 0.80 | 0.76—0.84 | <0.001 |
| High | 0.49 | 0.44—0.55 | <0.001 |
| Urbanization level | |||
| Urban | 1 | -- | -- |
| Suburban | 1.17 | 1.11—1.23 | <0.001 |
| Rural | 1.39 | 1.32—1.48 | <0.001 |
| Diabetes | 1.57 | 1.49—1.65 | <0.001 |
| Hypertension | 1.77 | 1.68—1.85 | <0.001 |
| Coronary artery disease | 1.43 | 1.37—1.50 | <0.001 |
| Hyperlipidemia | 0.89 | 0.84—0.93 | <0.001 |
| History of alcohol intoxication | 1.46 | 1.20—1.76 | 0.001 |
| Malignancies | 1.06 | 0.99—1.14 | 0.122 |
| Charlson Comorbidity Index score | |||
| 0 | 1 | -- | -- |
| 1 | 1.37 | 1.29—1.45 | <0.001 |
| ≥ 2 | 1.57 | 1.47—1.67 | <0.001 |
| Heart failure | 1.11 | 1.03—1.21 | 0.008 |
| Atrial fibrillation | 1.42 | 1.26—1.60 | <0.001 |
| Smoking | 0.99 | 0.79—1.24 | 0.937 |
| Obesity | 1.13 | 0.83—1.56 | 0.433 |
| Epilepsy | 2.13 | 1.85—2.45 | <0.001 |
| Peripheral artery disease | 1.06 | 0.93—1.21 | 0.384 |
Statistical results with p<0.05 were presented in boldface.