. 2014 Nov 21;6(9):82. doi: 10.1186/s13195-014-0082-1

Table 2.

Summary of methodological approaches used in the community-based neuropathological studies summarized in this review

Study	n	Neuropathological criteria					Aβ	Tau	α-Syn	Ubi/p62	TDP-43	Vascular pathologies	HS
		BB	C	NR	NA	DLB/Br
MAP [27,30-33]	425	+	+	+		+^a	+	+	+			+	+
ROS [27,30,32-35]	539	+	+	+		+^a	+	+	+		+^b	+	+
MRC CFAS [21,36-39]	525	+	+			+^a,c	+	+	+	+		+	+
CC75C + [40]	224	+	+			+^a	+	+	+	+		+	+
Vantaa 85 + ^d [41-43]	304	+	+			+^a	+	+	+	+		+	+
Hisayama [44,45]	205	+		+		+^e		+	+	+		+
HAAS [46-48]	439	+	+			+^e			+	+		+	+
ACT [49,50]	438	+	+	+		+^e			+			+	+
BALS [51,52]	209	+	+			+^e			+			+
OBAS^d [53,54]	125	+	+	+		+^e		+	+			+	+
90+ Study^d [55]	108	+	+			+^e	+	+	+		+	+	+
VITA [5]	233	+	+	+	+	+^c	+	+	+	+	+	+	+

Aβ, amyloid beta; ACT, Adult Changes in Thought; α-Syn, α-synuclein; BALS, Baltimore Longitudinal Study of Ageing; BB, Braak and Braak staging for Alzheimer’s disease; Br, Braak; C, Consortium to Establish a Registry for AD criteria; CC75C, Cambridge City Over-75 s Cohort; DLB, McKeith criteria for dementia with Lewy bodies; HAAS, Honolulu–Asia Aging Study; HS, hippocampal sclerosis; MAP, Rush Memory and Aging Project; MRC CFAS, Medical Research Council Cognitive Function and Ageing Study; n, number of individuals included in the studies; NA, National Institute on Aging–Alzheimer’s Association criteria; NR, National Institute on Aging–Reagan criteria; OBAS, Oregon Brain Aging Study; ROS, Religious Orders Study; TDP-43,Tar-DNA binding protein 43; Ubi, ubiquitin; VITA, Vienna Trans-Danube Aging study. ^aDLB criteria 1996. ^bNot assessed in all participants. ^cBraak staging for Parkinson’s disease. ^dAge of autopsied cohort >90 years. ^eDLB criteria 2005.