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. 2014 Nov 19;12:319. doi: 10.1186/s12967-014-0319-6

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© Danza et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Clustering analysis of familial breast tumors. A) Unsupervised hierarchical clustering of fFBCs (BRCA-related and BRCAX) and FMBCs over 53 deregulated miRNAs (Pink indicates overexpressed miRNAs; blue indicates underexpressed miRNAs); B) Bootstrap analysis of the sample set by Consensus Clustering. Plot shows change in Gini correlation coefficient (ΔGn) with each additional group added, indicating that the optimal numbers of clusters is three; C) Red squares in the consensus matrix represent the subgroup of the sample set. fMBC: familial male breast cancer; fFBC: familial female breast cancer.