Figure 1.

5-Aza-dC ameliorates atherosclerosis development in Ldlr^−/− mice. A, Representative cross-sectional image of aortic sinus stained with Oil Red O. B, Quantification of aortic lesion area. C, Representative images of aortic surface lesions. D, Aortic surface lesion area normalized to total aortic surface area. Eight-week-old male Ldlr^−/− mice (n = 6 per group) were fed an atherogenic diet and were ip injected with either saline or 5-aza-dC (0.25 mg/kg body weight) 3 times a week. Quantification of atherosclerosis was conducted as described in Materials and Methods. For B and D, data are expressed as mean ± SEM; n = 6 per group. *, P < .05; **, P < .01.