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Disruption of HSP20–PDE4D complex reverses MTAB induced cardiac dysfunction. Histograms of % fractional shortening (A) and post-mortem heart weight to body weight ratios (B) Mice undergoing sham or MTAB surgery were treated with either 10 mg/kg bs906 or control twice (i) or once weekly (ii) for 4 weeks. Data represent mean ± S.E.M., n = 3–8, ∗p < 0.05 ∗∗p < 0.01, ∗∗∗p < 0.001, ns = p > 0.05, one-way ANOVA post hoc Tukey’s test.
