Cardiac fibrosis is modulated with disruption of HSP20–PDE4D complex. Picrosirius red staining of sham and MTAB hearts following treatment with 10 mg/kg bs906 or control peptide twice weekly (A). Histogram values (B) represent stained area expressed as a percentage of the total area of interest. Data represents mean ± S.E.M., n ⩾ 6, ∗∗p < 0.01, ∗∗∗p < 0.001, ns = p > 0.05, one-way ANOVA post hoc Tukey’s test.