FIGURE 5.

-Fold changes in deuterium uptake from free STAT3 are shown for STAT3 complexed with SF-1-066 (A) and STAT3 complexed with BP1–102 (B) are shown. Hot spots of differential deuterium uptake mapped onto the crystal structure of STAT3 (Protein Data Bank code 1BG1) are color-coded as decreases (blue shading) or increases (red shading) in uptake. Insets show a magnified view of the SH2 domain depicted from the face of the predicted inhibitor-binding pocket. The domain organization of STAT3 is mapped on the left.