. 2014 Sep 30;289(47):32639–32655. doi: 10.1074/jbc.M114.589689

TABLE 3.

Correlation of HBx protein expression with DNMT1, DNMT3A, DNMT3B, MAT1A, GR protein expression, and patients' clinicopathologic characteristics in hepatocellular carcinomas and noncancerous tissues

The correlations between the protein expression and tissue types were analyzed using a χ² or Fisher's exact test.

Characteristic		HBx expression HCC tissues		Correlation	p value	HBx expression noncancerous tissues		Correlation	p value
Characteristic		Negative	Positive	Correlation	p value	Negative	Positive	Correlation	p value
DNMT1 expression	Negative	14	3	0.557	0.010^a	19	2	0.600	0.016^a
DNMT1 expression	Positive	2	6	0.557	0.010^a	1	3	0.600	0.016^a
DNMT3A expression	Negative	5	5		0.870	11	4		0.615
DNMT3A expression	Positive	8	7		0.870	9	1		0.615
DNMT3B expression	Negative	1	12	−0.923	0.000^a	3	1		1.000
DNMT3B expression	Positive	12	0	−0.923	0.000^a	17	4		1.000
MAT1A expression	Negative	18	2	0.656	0.005^a	7	3	0.500	0.034^a
MAT1A expression	Positive	1	4	0.656	0.005^a	3	12	0.500	0.034^a
GR expression	Negative	4	3		1.000	8	8		0.428
GR expression	Positive	8	9		1.000	7	3		0.428
Sex	Male	10	10		1.000	16	4		1.000
Sex	Female	3	2		1.000	4	1		1.000
Liver cirrhosis	No	6	2	0.557	0.010^a	5	3		0.673
Liver cirrhosis	Yes	3	14	0.557	0.010^a	8	9		0.673
AFP (ng/ml)	≤ 200	3	0	0.538	0.024^a	2	1		0.543
AFP (ng/ml)	>200	5	17	0.538	0.024^a	8	14		0.543

^a p < 0.05 was considered significant.