TABLE 1.
Mean arteriole and venule permeability in the presence or absence of SU5416
Permeability (Ps) was calculated from the increase in fluorescent intensity immediately outside of the microvessel over time adjusted for microvessel surface area, initial Alexa-488-BSA concentration gradient, and source volume.
| Genotype/treatment | Arteriole Ps ± S.E. × 10−6 cm/s | Venule Ps ± S.E. × 10−6 cm/s | Number of vessel sites | Number of mice |
|---|---|---|---|---|
| Krit1+/+ | 0.53 ± 0.13 | 0.66 ± 0.16 | 20 | 5 |
| Krit1+/+ +SU5416 | 0.8563 ± 0.1198 | 0.78 ± 0.09 | 17 | 3 |
| Krit1+/− | 1.65 ± 0.25 | 1.38 ± 0.24 | 27 | 5 |
| Krit1+/− +SU5416 | 0.68 ± 0.08 | 0.55 ± 0.06 | 24 | 4 |
| Krit1+/− +vehicle | 1.24 ± 0.34 | 1.16 ± 0.14 | 20 | 3 |