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. Author manuscript; available in PMC: 2015 Aug 7.
Published in final edited form as: Cell Stem Cell. 2014 Aug 7;15(2):114–116. doi: 10.1016/j.stem.2014.07.004

Figure 1. The role of the nuclear orphan receptor TLX (NR2E1) in glioblastoma.

Figure 1

TLX-positive glioma cells are quiescent and display the capacity for self-renewal and tumor growth. TLX marks a subpopulation of tumor cells distinct from other putative cancer stem cell (CSC) markers – SOX2 and OLIG2 – suggesting the potential for different pools of CSCs or further stages in a cellular hierarchy with SOX2 potentially indicating a transient amplifying progenitor population