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. Author manuscript; available in PMC: 2014 Nov 21.
Published in final edited form as: J Peripher Nerv Syst. 2009 Dec;14(4):257–267. doi: 10.1111/j.1529-8027.2009.00237.x

Fig. 5. High glucose and oxLDL cause cell death in DRG neurons via NAD(P)H Oxidase.

Fig. 5

Adult DRG neurons were exposed to high glucose (25.7 mM) or increasing concentrations of oxLDL and then cell death was quantitated by caspase 3 activation after 5 h. DRG neurons were additionally pre-treated with LOX-1 neutralizing antibody (Anti-LOX-1, 100 mg/ml), apocyanin (Apo, 1 μM), or α-lipoic acid (LA, 100 μM). n=9, *p<0.01 compared to untreated control, +p<0.01 compared to no pre-treatment (None). (B) Adult DRG neurons were exposed to 30 μg/ml oxLDL and then immunolabeled for NAD(P)H oxidase subunits p47 or gp91. In (B), adult DRG neurons were exposed to high glucose (25.7 mM) or oxLDL (30 μg/ml) for 1 h or 3 h, then lysed for biochemical assays of NAD(P)H oxidase. *p<0.01 compared to untreated control, +p<0.05 compared to untreated control. (reproduced from (Vincent, et al., 2009b)).