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. Author manuscript; available in PMC: 2014 Nov 21.
Published in final edited form as: Rev Endocr Metab Disord. 2008 Dec;9(4):301–314. doi: 10.1007/s11154-008-9104-2

Figure 3. Methodologies in Biomarker Research [49].

Figure 3

Activities in white are hypothesis driven and attempt to identify biomarkers based on the disequilibrium of identified targets in diabetic neuropathy, leading to an abnormal accumulation of products, such as modified proteins or small molecules. Activities in grey are discovery oriented and seek to identify features of the data set that are predictive of diabetic neuropathy without necessarily corresponding to a single target. (Reprinted from Pharmacol Ther. 2008 Jun 13. Diabetic neuropathy: Mechanisms to management, Edwards JL, Vincent AM, Cheng HL, Feldman EL Copy right 2008 with permission form Elsevier).