Table 1.
Rodent Models of Diabetic Neuropathy and Oxidative Stress.
| Rodent Model of Diabetes | Duration of Diabetes | Neuropathy Assessment | OX Stress Measurements | Reference |
|---|---|---|---|---|
| STZ-induced | ||||
| DBA/2J mice | 24 wk | NCV Behavior |
NT HODEs |
Wiggin 2008 (57) |
| Wistar rats | 6 and 12 wk | MNCV | Hexokinase | Gardiner 2007 (58) |
| Sprague–Dawley rats | 8 wk 2 or 8 wk endaravone |
MNC NBF Behavior |
LPO SOD Catalase |
Saini 2007 (59) |
| Sprague–Dawley rats | 6 wk untreated 2 wk reseratrol |
MNCV NBF Behavior |
MDA Peroxynitrite Catalase |
Kumar 2007 (60) |
| Sprague–Dawley rats | 4–12 wk untreated 12 wk enalapril/L-158809 |
MNCV NBF |
O2•− | Coopey 2006 (61) |
| Male Wistar rats | 2 wk untreated 2 wk ISO |
Behavior | NT PAR O2•− |
Ilnytska 2006 (62) |
| Sprague–Dawley rats | 2 wk untreated 10 wk fidarestat |
MNCV NBF |
GSH 8-OHdG Sorbitol |
Kuzumoto 2006 (63) |
| Sprague–Dawley rats | 6 wk untreated 2 wk U83836E |
MNCV NBF Behavior |
SOD Catalase MDA |
Sayyed 2006 (64) |
| Sprague–Dawley rats | 6 wk untreated 2 wk troxol |
MNCV NBF Behavior |
SOD Catalase LPO NOS |
Sharma and Sayyed 2006 (65) |
| Sprague–Dawley rats | 4, 12, 52 wk | MNCV SNCV |
8-OHdG | Schmeichel 2003 (66) |
| C57BL6 mice | 8 wk untreated 1 wk FP15 |
MNCV SNCV |
NT PCr/Cr Sorbitol, Glucose, Fructose |
Obrosova 2005 (67) |
| COX-2 KO mice | 24 wk | MNCV SNCV INFD |
MDA O2•− GSH PG |
Kellogg 2007 (68) |
| AR KO mice | 4, 8, 12 wk | MNCV SNCV |
JNK activation GSH O2•− DNA damage Sorbitol 8-OHdG |
Ho 2006 (69) |
| Galactose-induced Wistar rats PARP KO mice |
4 wk untreated 2 wk 3-aminobenzamide 13 wk |
MNCV SNCV NBF |
PAR PCr/Cr Nerve energy failure |
Obrosova 2004 (70) |
| Spontaneous | ||||
| ZDF rats | 8–40 wk old | MNCV NBF |
NT O2•− |
Oltman 2005 (71) |
| BKS.Cg-m+/+Leprdb/J (BKS-db/db) C57BL/6J STZ-induced |
24 wk old | MNCV SNCV Behavior INFD |
NT | Sullivan 2007 (55) |
| B6.V-Lepob/J | 8 wk old untreated 3 wk FP15/FeTMPS |
MNCV SNCV Behavior INFD |
NT PAR |
Vareniuk 2007 (72) |
| B6.V-Lepob/J | 5 wk old untreated 6 wk fidarestat |
MNCV SNCV Behavior INFD |
NT PAR |
Drel 2006 (73) |
| C57BL6/J High-fat diet | 16 wk old High-fat diet | MNCV SNCV Behavior INFD |
NT 4-HNE PAR 12/15-lipoxygenase Sorbitol |
Obrosova 2007 (74) |
4-HNE, Aminoacid-(4)-hydrosynonenal adducts; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; AR, Aldose reductase; FeTMPS, Fe(III) tetra-mesitylpophyrin octasulfonate; FP15, Fe(III) tetrakis-2-(N-trethylene glycol monomethyl ether)-pyridyl porphyrin; ISO, 1,5-isoquinolinediol; LPO, lipid peroxidation; MDA, malondialdehyde; MNCN, Motor nerve conduction velocities; NBF, Nerve blood flow; NT, Nitrotyrosine; O2•−, Superoxide; PAR, poly(ADP)-ribose; PCr/Cr, phosphocreatinine/creatinine ratio; PG, Prostaglandin content; SNCV, Sensory nerve conduction velocities; SOD, Superoxide dismutase; STZ, Streptozotocin; ZDF, Zucker diabetic fatty.