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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Nov 27;107:93–100. doi: 10.1016/j.nlm.2013.11.008

Figure 1. Intra-LA infusion of an inhibitor of DNMT activity impairs fear memory consolidation and training-related neural plasticity in the LA.

Figure 1

(a) Rats were habituated to handling and given two days of baseline recording sessions in which AEFPs were recorded from the LA. On the 4th day, rats were fear conditioned with 3 tone pip series (CS)-shock (US) pairings followed 1 hr later by intra-LA infusion of either vehicle (n = 6), RG108 (500 ng/side; n = 6) or 5-AZA (500 ng/side; n = 6). Rats in each group were then tested for STM and LTM 3 and 21 hrs later, respectively, while AEFPs were recorded from the LA. (b) Mean (± SEM) percent freezing during the STM and LTM tests in vehicle, RG108 and 5-AZA infused groups. *p<0.05 relative to vehicle-infused controls. (c) Mean (± SEM) percent of change in AEFP amplitude during the STM and LTM tests in vehicle, RG108 and 5-AZA-infused rats, relative to baseline. *p<0.05 relative to vehicle-infused controls. (d) Correlation between freezing scores and AEFP amplitudes in RG108- and 5-AZA-treated rats during the LTM test, each expressed as a percentage of freezing and AEFP amplitude change during the STM test. (e) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), STM and LTM sessions (darker traces). Scale bar =10 μV, 5ms.