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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Nov 27;107:93–100. doi: 10.1016/j.nlm.2013.11.008

Figure 3. Intra-LA infusion of an inhibitor of DNMT activity in the absence of fear memory retrieval has no effect on fear memory reconsolidation or the retention of memory-associated neural plasticity in the LA.

Figure 3

(a) Rats were given two days of baseline AEFP recording sessions, followed by fear conditioning with three tone pip series (CS)-shock (US) pairings. Twenty four hrs following training rats were given a ‘no reactivation’ session in which they were placed in the testing context but not presented with a tone pip series. One hour following the ‘no reactivation’ session, rats received infusion of vehicle (n = 5), RG108 (500 ng/side; n = 5) or 5-AZA (500 ng/side; n = 4). Rats in each group were then tested for ‘PR’-STM and ‘PR’-LTM 3 and 21 hrs later, respectively, while AEFPs were recorded from the LA. (b) Memory retrieval data for the vehicle, RG108 and 5-AZA-infused groups during the ‘no reactivation’ session. (c) Mean (± SEM) percent freezing during the ‘PR’-STM and ‘PR’-LTM tests in vehicle, RG108 and 5-AZA-infused groups. (d) Mean (± SEM) percent change in AEFP amplitude during the ‘PR’-STM and ‘PR’-LTM tests in vehicle, RG108 and 5-AZA-infused rats, relative to baseline. (e) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), ‘PR’-STM and ‘PR’-LTM sessions (darker traces). Scale bar =10 μV, 5ms.