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Grey shading represents the doses of lamivudine (in milligrams per day) needed to reach the range for AUC0–24h observed in adults (from 8.9 to 16.6 mg h−1 l−1) as a function of creatinine clearance (in millilitres per minute). The lines represent FDA dosing recommendations (A) and dosing recommendations derived from the present study (B). 
, optimal exposure
