Figure 5.

(A) Box plots of AUC_0–24h derived from Monte Carlo simulations of 300 mg day⁻¹ in patients with creatinine clearance from 50 to 80 ml min⁻¹ (mild renal impairment) and in patients with normal renal function. (B) Box plots of AUC_0–24h derived from simulations of 200 mg day⁻¹ in patients with mild renal impairment and of 300 mg day⁻¹ in patients with normal renal function. , creatinine clearance 50–80 ml min⁻¹; □, normal creatinine clearance