Table 3.

Comparison of different limited sampling strategy (LSS) in 500 simulated PK profiles

Sampling times (h post-dosing)	Bias between observed and predicted AUC (mean)	Bias SE (%)	RMSE (%)	Percentage of patients with a bias greater than ± 20%
0.33-1-3	−0.002	15.82	15.8	60
0.33-1-4	7.45	20.74	22.02	117
0.33-3-4	8.53	24.36	25.79	136
0.66-1-3	0.66	17.68	17.67	74
0.66-2-3	−1.90	19.37	19.45	98
0.66-3-4	3.71	22.30	22.59	100