Table 2.
Population pharmacokinetic parameters
| Pharmacokinetic parameters | Estimate | RSE (%) |
|---|---|---|
| θCL (l h−1 kg−1) | 6.6 | 11 |
| θBW (CL(BWi) = θCL × BWi3/4) | 0.75 (fixed) | NA |
| θq0 (μg h−1 kg−1) | 3.12 | 23 |
| θBW (q0(BWi) = θq0 × BWi3/4) | 0.75 (fixed) | NA |
| V (l) for a 10 kg individual | 0.8 | NA |
| t1/2 (min), for a 10 kg individual | 0.9 | NA |
| ηCL (square root of ω2CL) | 0.6 | 14 |
| ηq0 (square root of ω2q0) | 1.1 | 17 |
| Residual variability (proportional) | 0.25 | 17 |
The volume of distribution of norepinephrine was ascribed to the circulating volume, estimated as a function of bodyweight, V = 0.08 × BW CL, elimination clearance; q0, endogenous production rate; V, volume of distribution; θCL, typical unit clearance; θq0, typical unit endogenous production rate; θBW, bodyweight influential parameter; t1/2, half-life; RSE (%), relative standard error; η, between subject variability (BSV); BW, bodyweight; NA, not applicable.