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. 2014 Sep 19;78(4):898–907. doi: 10.1111/bcp.12402

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© 2014 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Cumulative numbers of patients contributing PK information and (B) median numbers of PK samples per patient in 25 programmes conducting at least one PK trial, stratifying randomization into PK studies by age and stipulating intended sampling schedules. Numbers in each age group are based on programmes developing in that age group. Three (of 25) programmes obtain (some) PK samples from urine or saliva.(A) Cumulative PK patient numbers. , total; , 0–27 days; , 1–23 months; , 2–11 years; , 12–17 years and (B) median numbers of PK samples per patient. , non-orphan; , orphan

Inline graphic — (A) Cumulative numbers of patients contributing PK information and (B) median numbers of PK samples per patient in 25 programmes conducting at least one PK trial, stratifying randomization into PK studies by age and stipulating intended sampling schedules. Numbers in each age group are based on programmes developing in that age group. Three (of 25) programmes obtain (some) PK samples from urine or saliva.(A) Cumulative PK patient numbers. , total; , 0–27 days; , 1–23 months; , 2–11 years; , 12–17 years and (B) median numbers of PK samples per patient. , non-orphan; , orphan