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The kinase-active PFK-2 transgene increases glycolysis in Langendorff-perfused hearts. A and C: glycolysis (A) and lactate release (C) without palmitate. B and D: glycolysis (B) and lactate release (D) in the presence of 0.4 mM palmitate. The shaded box shows the addition of 200 μU/ml insulin. Values for FVB and Mk hearts were compared by two-way ANOVA (*P < 0.05). Values are means ± SE for at least 5 mice/time point.
