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The Mk transgene reduces palmitate oxidation in Langendorff-perfused hearts. A: FVB palmitate oxidation values were greater than Mk values at all time points (P < 0.01 by two-way ANOVA, n = 5 FVB and 7 Mk hearts). B: effect of insulin on palmitate oxidation by replotting the 30- and 80-min results from A. Insulin reduced palmitate oxidation by 32% in FVB hearts and by 42% in Mk hearts (#P < 0.01 by paired t-test).
