Figure 3.

Daily average alcohol intake during the 2-hour alcohol access period from 6 days prior to smoke exposure (Day -6 to Day 0) until 16 days after the tobacco smoke exposure. The arrow represents the first day of smoke exposure at 1 cigarette per 10-min cycle. Days 1-3 were designed as the adolescent “binge” of smoking (2 cigarettes per cycle on Day 2, and 3 cigarettes per cycle on Day 3), which did not cause a significant change in alcohol intake for the smoke-exposed group (open circles; 0.8 ± 0.19 g/kg, n=20) relative to the control group (closed circles; 0.6 ± 0.005, n=19; p>0.3). On Days 4 through 12, one cigarette per cycle was used, with an initial 5-foldpeak increase in drinking that decreased to a 3-fold level above the control group. From Day 13 to Day 16, 2 cigarettes per 10-min cycle were used (initiated on the day indicated by the triangle), yet the alcohol intake remained stable at about 3-fold above the control values.*p < 0.01.