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Effects of IL-1β and Ac-SDKP on TIMP-1 and TIMP-2 levels in cardiac fibroblasts. Cardiac fibroblasts were synchronized and treated with either vehicle, Ac-SDKP, IL-1β, or Ac-SDKP+IL-1β. TIMP-1 and TIMP-2 in the conditioned medium were detected by immunoblotting. a, c Bar diagrams representing the effects of IL-1β and Ac-SDKP on TIMP-1 level. b, d Bar graphs representing the effects of IL-1β and Ac-SDKP on TIMP-2 level. Each bar represents pooled data from three separate experiments
