Table 1.
Body weight, lung weight and echocardiography
| Control | Ac-SDKP | Ang II | Ang II + Ac-SDKP | |
|---|---|---|---|---|
| Number of rats | 14 | 13 | 16 | 14 |
| BW(g) | 319 ± 7 | 312 ± 8 | 263 ± 5** | 272 ± 5 |
| LWW/TL (mg/cm) | 54.0 ± 3.5 | 61.6 ± 3.8 | 55.5 ± 2.7 | 56.0 ± 1.8 |
| HR | 383 ± 10 | 358 ± 16 | 353 ± 11 | 331 ± 11 |
| IVSTs (mm) | 2.81 ± 0.10 | 2.79 ± 0.06 | 3.29 ± 0.06*** | 2.97 ± 0.07†† |
| IVSTd (mm) | 1.59 ± 0.04 | 1.65 ± 0.04 | 1.97 ± 0.03*** | 1.89 ± 0.05 |
| PWTs (mm) | 2.79 ± 0.05 | 2.76 ± 0.08 | 3.09 ± 0.06*** | 3.07 ± 0.08 |
| PWTd (mm) | 1.63 ±0.03 | 1.66 ± 0.04 | 2.08 ± 0.05*** | 2.09 ± 0.08 |
| LVDs (mm) | 2.62 ± 0.15 | 2.96 ± 0.16 | 1.97 ± 0.14** | 2.42 ± 0.12† |
| LVDd (mm) | 5.60 ± 0.16 | 5.70 ± 0.19 | 4.81 ± 0.15** | 4.98 ± 0.19 |
| LVAs (mm2) | 6.75 ± 0.61 | 7.29 ± 0.81 | 4.83 ± 0.54* | 5.78 ± 0.72 |
| LVAd (mm2) | 24.65 ± 1.06 | 24.22 ± 1.72 | 20.40 ± 1.25* | 21.19 ± 1.16 |
| SF (%) | 53.4 ± 2.2 | 48.3 ± 2.0 | 59.3 ± 2.2 | 51.5 ± 1.2†† |
| EF (%) | 72.6 ± 2.0 | 70.6 ± 1.7 | 76.9 ± 1.5 | 73.4 ± 1.9 |
| CO (ml/min/100 g) | 29.9 ± 2.8 | 30.1 ± 3.5 | 33.8 ± 2.8 | 30.3 ± 2.1 |
| E/A ratio | 1.46 ± 0.08 | 1.58 ± 0.03 | 1.23 ± 0.12 | 1.46 ± 0.08 |
| EDT(ms) | 29.0 ± 1.7 | 28.8 ± 1.3 | 27.4 ± 1.8 | 29.3 ± 0.9 |
BW = body weight (g); HR = heart rate (beats/min); LWW = lung wet weight, TL = tibia length. IVSTs/d = interventricular septum thickness in systole and diastole; PWTs/d = posterior wall thickness in systole and diastole; LVDs/d = left ventricular dimension in systole and diastole; LVAs/d = left ventricular area in systole and diastole; SF (%) = shortening fraction; EF (%) = ejection fraction; CO = cardiac output/100 g; E/A ratio = ratio between E/A waves. EDT: deceleration time of the early mitral filling wave (ms = milliseconds).
*
p < 0.05,
**
p<0.01, and
***
p < 0.001, Ang II vs. control;
†
p < 0.05 and
††
p < 0.01, Ang II + Ac-SDKP vs. Ang II.