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. 2014 Sep 2;104(2):347–354. doi: 10.1093/cvr/cvu201

Figure 1.

Figure 1

The effects of ISO on Ca signalling in ventricular myocytes from WT and PLN-KO mice. (A) Timecourse of effects on a WT cell. The cell was stimulated with voltage-clamp pulses. Caffeine/BDM (caff) and ISO (100 nM) were applied as shown. (B) Expanded records of the effects of applying caffeine (5 mM, for the period shown by the horizontal bars) to measure SR Ca content. Traces show (from top to bottom): Ca, membrane current, and integrated current. (C) Timecourse of effects on a PLN-KO cell. (D) Expanded records of the effects of applying caffeine/BDM to measure SR Ca content. (E) Amplitude of the systolic Ca transient. (F) Rate constant of decay of the systolic Ca transient. (G) Amplitude of the caffeine-evoked increase of Ca. (H) Calculated SR Ca content. *P < 0.05; **P < 0.01; ***P < 0.001. PLN-KO: n = 8–9 cells/6 animals; WT: n = 12 cells/5 animals.