Table 5.

Results for SNPs that reach genome-wide significance (P < 5 × 10⁻⁸) in the WHI-SHARe African Americans

SNP	Chr	Pos	Gene	Location	RDB	A1	A2	African-American incident					African-American prevalent
								r2	Case	Non-case	HR/OR	P	Case	Non-case	HR/OR	P
rs542340	11	31 409 438	DNAJC24	Intron	–	G	A	0.72	0.028	0.018	1.86 (1.4,2.48)	2.1 × 10−5	0.032	0.019	2.1 (1.45,3.039)	8.5 × 10−5
rs555091	11	31 532 959	ELP4	Intron	5	C	T	0.728	0.029	0.018	1.85 (1.39,2.47)	2.3 × 10−5	0.032	0.02	2.037 (1.4,2.97)	2e−04
rs506227	11	31 537 439	ELP4	Intron	–	T	C	0.741	0.028	0.018	1.83 (1.38,2.44)	3.4 × 10−5	0.032	0.02	2.026 (1.39,2.95)	0.00023
chr14:51604618:I	14	51 604 618	TRIM9- TMX1	Intergenic	–	TG	T	0.609	0.031	0.02	2.075 (1.54,2.8)	1.6 × 10−6	0.03	0.022	1.88 (1.23,2.88)	0.0036
rs192917960	16	5 919 655	FAM86A- RBFOX1	Intron	–	T	C	0.862	0.032	0.015	2.14 (1.65,2.78)	1.2 × 10−8	0.022	0.018	1.31 (0.86,2.0049)	0.21
	African American combined		Hispanic incident					Hispanic prevalent				Hispanic combined
SNP	HR/OR	P	r2	Case	Non-case	HR/OR	P	Case	Non-case	HR/OR	P	HR/OR	P	Effect
rs542340	1.95 (1.55,2.44)	8.0 × 10−9	0.669	0.001	0.001	–	–	0.001	0.001	–	–	–	–	++(+)??(?)
rs555091	1.92 (1.53,2.41)	1.9 × 10−8	0.678	0.001	0.001	–	–	0.001	0.001	–	–	–	–	++(+)??(?)
rs506227	1.9 (1.51,2.39)	3.3 × 10−8	0.72	0.001	0.001	–	–	0.001	0.001	–	–	–	–	++(+)??(?)
chr14:51604618:I	2.009 (1.57,2.57)	2.2 × 10−8	0.62	0.051	0.043	1.34 (0.88,2.052)	0.17	0.034	0.044	0.71 (0.31,1.6)	0.4	1.17 (0.81,1.71)	0.41	++(+)+−(+)
rs192917960	1.87 (1.5,2.33)	3.6 × 10−8	0.742	0.004	0.004	–	–	0.001	0.004	–	–	–	–	++(+)+−(?)

RDB, Regulome database score.