Table 5.

Association results for Aβ_1–42 and rs62256378 according to sample and APOE strata

Stratuma	rsb	chrc	bpd	Minore	Majorf	Bonn1CSF			Bonn2CSF			ADNI			ADC			Meta-analysis
						βg	SEh	Pi	βg	SEh	βi	βg	SEh	Pi	βg	SEh	Pi	βg	SEh	Pi
ALL	rs429358 (e4)	19	45 411 941	ε4	ε4(−)	−0.51	0.11	6.1 × 10−6	−0.33	0.07	5.9 × 10−7	−0.39	0.15	0.01	−0.70	0.15	1.1 × 10−5	−0.40	0.05	4.3 × 10−17
ALL	rs62256378	3	67 457 033	A	G	2.13	0.46	2.5 × 10−5	0.82	0.24	6.0 × 10−4	0.50	0.29	0.09	0.61	0.13	1.9 × 10−6	0.71	0.10	2.5 × 10−12
APOE-ε4 noncarriers	rs62256378	3	67 457 033	A	G	1.68	0.57	4.8 × 10−3	0.96	0.36	8.8 × 10−3	0.66	0.43	0.14	0.94	0.24	1.1 × 10−4	0.97	0.17	1.5 × 10−8
APOE-ε4 heterozygous	rs62256378	3	67 457 033	A	G	0.24	0.30	0.44	0.45	0.22	0.04	0.48	0.49	0.33	0.32	0.15	0.03	0.35	0.11	1.5 × 10−3
APOE-ε4 homozygous	rs62256378	3	67 457 033	A	G	–	–	–	−0.13	0.33	0.71	−0.10	0.76	0.90	0.01	0.25	0.96	−0.04	0.19	0.83

^aAnalysis of all patients and within strata defined by APOE-ε4 carrier status.

^brs number.

^cChromosome.

^dPhysical position in base pairs, according to dbSNP build 37.

^eMinor allele.

^fMajor allele.

^gEffect estimate from regression analysis. Represents increase in Aβ_1–42 levels in standard deviations per minor allele.

^hStandard error of effect estimate.

ⁱP-value; ADNI, Alzheimer's Disease Neuroimaging Initiative cohort; ADC, Amsterdam Dementia Cohort.