Table 1.

Meta-analysis results for loci that reached or marginally reached genome-wide significance (P < 5 × 10⁻⁸)

Chr	Nearest gene(s)	Lead SNP	Positiona	EAFb	Effect allele	Other allele	βc in individual study					βc	SE	P	% Variance explained	I2	Cochran's Q (P)	P for association with FNBMDd	P for association with LSBMDd
							FHS	GOOD	HKOS	MICROS	WHI
Sex-combined meta-analysis
8	COLEC10, MAL2, TNFRSF11B	rs1425053	120 282 171	0.607 (0.713)	A	T	0.039	0.034	0.045	0.033	0.016	0.037	0.0048	8.15 × 10−15	0.58	0	0.80	0.047	0.24
17	FLJ40504, POLDIP2, TMEM97, MIR4723, VTN, IFT20, SARM1, TNFAIP1, SLC46A1, TMEM199, SEBOX	rs704	23 718 988	0.494 (0.701)	A	G	−0.027	−0.027	−0.034	−0.051	−0.045	−0.030	0.0049	1.46 × 10−9	0.35	0	0.74	7.07 × 10−3	0.025
14	—	rs2488856	42 601 152	0.898 (NA)	A	C	−0.048	−0.051	NA	−0.027	0.023	−0.044	0.0080	5.45 × 10−8	0.28	33	0.21	0.39	0.55
Female-specific meta-analysis
8	COLEC10, MAL2, TNFRSF11B	rs2468186	120 269 883	0.623 (0.698)	T	C	0.045	–	0.047	0.027	0.019	0.040	0.0070	8.46 × 10−9	0.59	0	0.56	0.45	0.45

Note: the LD r² between rs1425053 and rs2468186 is >0.9 in both European and Chinese populations in HapMap.

Chr, chromosome.

^aPositions are according to NCBI Build 36.

^bEffect allele frequency (EAF) averaged from the samples, with the Chinese EAF specifically indicated in brackets.

^cβ represents the change in the natural log-transformed serum OPG levels (pmol/l) per additional copy of the effect allele.

^dP-value for association with BMD from a published meta-analysis (42).