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. 2014 Jun 10;5(11):1107–1116. doi: 10.1021/cn5000919

Figure 1.

Figure 1

Comparison of metabotropic cannabinoid receptors and TRP channel ionotropic cannabinoid receptors. (A) Metabotropic receptors are seven transmembrane domain-containing proteins that signal via heterotrimeric G proteins. Typical responses resulting from the activation of Gi/Go G proteins by CB1 and CB2 receptors are shown. (B) TRP channel subunits each have six transmembranes domains. Four subunits assemble to form a function channel to mediate influx of sodium and/or calcium ions. ARD, ankyrin repeat domains.