Table 4.
Pre- and Early Post-TPV Echocardiographic, MRI, and Exercise Test Data on Patients With Paired Preimplantation and 6-Month Postimplantation Testing
| Variable | Pre-TPV | 6-Month Post-TPV | P |
|---|---|---|---|
| Echocardiography (n=98) | |||
| RV pressure, mm Hg | 73.5±17.9 | 55.0±14.6 | 0.001 |
| Median (range) | 74.0 (33–149) | 51.0 (29–106) | |
| Mean RVOT gradient, mm Hg | 33.4±15.0 | 20.0±8.6 | 0.001 |
| Median (range) | 34.3 (8–80) | 17.5 (7–52) | |
| Maximum instantaneous RVOT gradient, mm Hg | 55.0±23.1 | 32.9±13.8 | 0.001 |
| Median (range) | 54.8 (14–130) | 29.2 (13–88) | |
| MRI (n=80) | |||
| RV end-diastolic volume, mL | 205.8±90.2 | 172.7±76.3 | 0.001 |
| Median (range) | 173 (93–574) | 152 (70–451) | |
| Indexed RV end-diastolic volume, mL/m2 | 125.1±49.2 | 103.0±39.5 | 0.001 |
| Median (range) | 111 (62–312) | 98 (48–253) | |
| RV ejection fraction, % | 43.2±14.1 | 42.6±12.3 | 0.9 |
| Median (range) | 43.8 (10–91) | 41.5 (8–68) | |
| RV mass, g | 67.3±27.3 | 57.5±19.3 | 0.001 |
| Median (range) | 62 (24–171) | 53 (25–114) | |
| PR fraction, % | 24.8±14.9 | 2.8±3.1 | 0.001 |
| Median (range) | 26.7 (0–61) | 1.8 (0–13) | |
| Cardiopulmonary exercise testing (n=93) | |||
| Peak relative V̇O2, mL · kg−1 ·/min−1 | 23.9±8.6 | 24.5±7.8 | 0.44 |
| Median (range) | 25.0 (9–59) | 24.9 (9–52) | |
| Percent of predicted peak V̇O2, % | 60.2±18.4 | 62.5±18.7 | 0.40 |
| Median (range) | 61 (20–122) | 63 (21–125) | |
| V̇E/V̇CO2 slope | 30.9±4.6 | 29.3±4.2 | 0.001 |
| Median (range) | 31 (21–48) | 29 (22–44) | |
| Respiratory exchange ratio | 1.11±0.12 | 1.13±0.12 | 0.01 |
| Median (range) | 1.11 (0.87–1.40) | 1.13 (0.88–1.37) | |
| ECG (n=90) | |||
| Heart rate, bpm | 70.4±12.2 | 69.8±13.3 | 0.62 |
| Median (range) | 70 (48–108) | 68 (40–108) | |
| QRS duration, ms | 142.7±32.4 | 142.1±35.2 | 0.73 |
| Median (range) | 146 (80–240) | 148 (61–242) |
Data are presented as mean±SD and median (range). The numbers of patients with follow-up data do not equal the number with clinical follow-up because of the time lag between clinical follow-up evaluation and core laboratory reading/entry of study data, as discussed in Methods, and MRI studies that were not performed because of pacemakers or metallic artifact.