Table 1.
Clinical and pathological features of 27 essential tremor cases and 27 controls
| Essential tremor cases | Controls | Significance | |
|---|---|---|---|
| Age at death (years) | 87.7 ± 7.4 | 85.0 ± 6.7 | P = 0.16a |
| Female gender | 14 (51.9) | 21 (77.8) | P = 0.046b |
| Age of tremor onset (years) | 40.3 ± 26.3 | Not applicable | Not applicable |
| Duration of tremor (years) | 47.5 ± 26.4 | Not applicable | Not applicable |
| Median post-mortem interval (h) | 2 | 5.25 | P = 0.001 |
| Brain weight (g) | 1212 ± 156 | 1176 ± 136 | P = 0.36a |
| Braak Alzheimer’s disease scorec | P = 0.16b | ||
| 0 | 2 (7.4) | 2 (18.2) | |
| 1 | 9 (33.3) | 3 (27.3) | |
| 2 | 4 (14.8) | 4 (36.4) | |
| 3 | 11 (40.7) | 1 (9.1) | |
| 4 | 1 (3.7) | 0 (0.0) | |
| 5 | 0 (0.0) | 0 (0.0) | |
| 6 | 0 (0.0) | 1 (9.1) | |
| CERAD scorec | P = 0.79b | ||
| 0 | 11 (40.7) | 4 (36.4) | |
| A | 10 (37.0) | 5 (45.5) | |
| B | 4 (14.8) | 2 (18.2) | |
| C | 2 (7.4) | 0 (0.0) | |
| Torpedo count (Luxol Fast blue and counterstained with haematoxylin and eosin) | 17.7 ± 16.6 | 6.1 ± 7.5 | P = 0.018a |
| Torpedo count (Bielschowsky) | 25.8 ± 22.8 | 10.3 ± 10.3 | P = 0.02a |
| Purkinje cell count | 6.8 ± 1.8 | 8.5 ± 2.1 | P = 0.025a |
| Purkinje cell linear density (cells/mm) | 3.1 ± 0.8 | 3.9 ± 1.0 | P = 0.025a |
Values are mean ± standard deviation or number (percentage) unless specified otherwise.
aStudent t-test.
bChi-square test.
cData available on 11 rather than 27 control subjects.