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. 2013 Aug 23;280(19):4876–4887. doi: 10.1111/febs.12463

Figure 4.

Figure 4

Characterization of Fc constructs. (A) SPR analysis of coated Fc constructs with the indicated chemokines as analytes. Similar to Evasin-4, the Fc constructs showed good binding to CCL3, -5, -7, -11, -14, -15, -18 and -26. No binding between the Fc constructs and CCL2, CCL4 or CXCL8 was observed. CCL13 appears to be bound by Fc–Evasin-4 but not by Evasin-4–Fc. (B) Inhibition of CCL11-mediated chemotaxis using L1.2/CCR3 cells with increasing concentrations of the Fc constructs. Data are presented as mean of three experiments ± SD.