Table 3.
Inhibition of chemotaxis by Evasin-4. Data are presented as the mean of at least three experiments ± SD. –, no inhibition observed
| Chemokine | Cells | EC80 (nm) | IC50 Evasin-4 (nm) |
|---|---|---|---|
| CCL1 | L1.2/CCR8 | 0.1 | – |
| CCL2 | L1.2/CCR2 | 1 | 615 ± 276 |
| CCL3 | L1.2/CCR5 | 40 | 4.4 ± 0.9 |
| 300.19CCR1 | 1 | 2.0 ± 0.5 | |
| CCL3L1 | L1.2/CCR5 | 1 | 3.5 ± 2.0 |
| CCL5 | Monocytes | 10 | 1.5 ± 1.1 |
| 300.19/CCR1 | 1 | 2.2 ± 1.2 | |
| L1.2/CCR5 | 1 | 4.8 ± 1.5 | |
| CCL7 | Eosinophils | 10 | 5.0 ± 2.8 |
| L1.2/CCR2 | 5 | 5.0 ± 3.2 | |
| CCL8 | Eosinophils | 10 | 3.1 ± 1.6 |
| L1.2/CCR3 | 5 | 3.6 ± 2.4 | |
| CCL11 | Eosinophils | 1 | 4.9 ± 1.5 |
| L1.2/CCR3 | 1 | 14.0 ± 4.2 | |
| CCL13 | L1.2/CCR2 | 10 | 167 ± 70 |
| CCL14 | 300.19/CCR1 | 1010 | 2.4 ± 1.3 |
| CCL15 | L1.2/CCR3 | 100 | 88 ± 51 |
| CCL16 | 300.19/CCR1 | 250 | 304 ± 20 |
| CCL17 | L1.2/CCR4 | 1 | 69 ± 24 |
| CCL19 | T lymphocytes | 10 | – |
| CCL21 | T lymphocytes | 10 | – |
| CCL22 | L1.2/CCR4 | 1 | 38 ± 25 |
| CCL23 | 300.19/CCR1 | 10 | 2.2 ± 0.4 |
| CCL24 | L1.2/CCR3 | 10 | 95 ± 31 |
| CCL25 | MOLT-4 | 100 | – |
| CCL26 | Eosinophils | 50 | 101 ± 63 |
| L1.2/CCR3 | 10 | 68 ± 30 |